الفهرس 
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Abstract
Summary : Echocardiography is an important cardiac imaging tool in patients with suspected cardiac disease. However, conventional echocardiography has a limited value in the diagnosis and risk stratification of suspected CAD patients as most of these patients with no previous myocardial infarction or myocardial stunning have no wall motion abnormalities at rest. So, finding another resting module to diagnose and predict the severity of CAD would be very beneficial. Speckle tracking echocardiography (STE) is a semiautomated software that allows fast, quantitative, and angle-independent assessment of the three components of myocardial deformation, with great feasibility and reproducibility particularly of the longitudinal one. Several clinical studies confirmed the feasibility of STE-derived longitudinal strain analysis as an adjunctive method for CAD detection. This study was conducted at Mansoura university hospitals aiming to evaluate the diagnostic accuracy of longitudinal strain by speckle tracking echo imaging in patients with chronic stable angina and evaluation of the severity of coronary artery disease in these patients. We included a total of 100 cases who were subjected to complete history taking, general and cardiac examination, along with routine laboratory investigations. Additionally, 2-d speckle tracking echocardiography and coronary angiography were ordered for all cases. Our study showed the following findings : • The mean age of the include cases was 52.84 years. • Males represented 59% of the included cases. • Hypertension was present in 24% of cases, while diabetes was reported by 48% of cases. • Smokers represented 45% of the included cases. • Lipid profile assessment revealed that the following four parameters had the following values: 226.28, 128.12, 39.53, and 180.12 mg/dl for cholesterol, LDL, HDL, and TGs respectively. • Left ventricular hypertrophy was detected in 39% of cases. • Ischemic changes were identified as follows; anterior (42%,), lateral (38%), and inferior (20%). • Ejection fraction had mean value of 58.17%. • Grade I diastolic dysfunction was present in 46% of cases while grade II was present in only 15% of cases. The remaining cases showed no diastolic dysfunction. • Regarding the number of affected coronary vessels, one vessel disease was identified in 42% of cases, while two-vessel disease was present in 38% of cases. The remaining subjects had three-vessel disease. • Gensini score had mean value of 24.37 in the included cases. • Global longitudinal strain had mean value of 26.47 (range, 16 – 44). • GLS had significant positive correlation with anterior and lateral ischemic changes. • GLS had a significant negative correlation with EF. However, no significant correlation was detected between it and diastolic dysfunction presence. • Most of the assessed strain parameters had significant correlation with Gensini score.