الفهرس 
Aim and Plan of the workOnly 14 pages are availabe for public view
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Abstract
The Ms.c thesis includes aim and plan of the work and three main chapters:
I- Aim and plan of the work
The work aimed to prepare and characterize some new hydrazone ligand and its metal complexes hoping to explore some effective compounds to be used in treatment of breast cancer.
Introduction This chapter includes an overview of previous researches for complexes of hydrazone ligand and its complexes and also their application.
II- Experimental This chapter contains the chemicals and instruments used in
Practical part of thesis as follow:
1) Preparation of ligand and its metal complexes.
2) characterization of the ligands (1) and its complexes using:
Physical techniques such as molar conductances and magnetic susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral analyses as IR, UV- Vis., 1HNMR, mass spectra and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of antitumor activity (Breast cancer)
iv. Results and discussion
This chapter includes characterization of the ligand and its complexes. The ligand (1) was prepared as follow: The ligand, (H3L) was synthesized by boiling (10.0 g, 1.4 mol) of Alanine amino acid in 50 cm3 of ethanol solution in the presence of 5 drops of Conc H2SO4 for two hours. Leave it to cool at room temperature to give alanine ester that was mixed with ( 8.0 g, 0.4 mol) hydrazine hydrate .The solution was refluxed with stirring for two hours at 80 oC, then left to cool at room temperature. The precipitated product was filtered off then dried under vacuum over anhydrous CaCl2. (5.0 g, 0.12 mol) of yeild reacts with (3.0 g, 0.04 mol) of salcylaldhyde in the presence of 50 cm3 of ethanol solution. The solution was refluxed for another two hours with stirring at 80 oC, then left to cool at room temperature. The precipitate was filtered off, and then dried under vacuum to give the ligand.
Physicochemical studies (IR, UV - Vis, Mass, 1H-NMR, magnetism , DTA and TGA, conductivity and ESR) were carried out. The measurements revealed that, the ligand coordinates to the metal ion in a neutral pentadentate or dibasic pentadentate mode through nitrogen atoms of imino group and oxygen atom of the hydroxyl group. All metal complexes are non-electrolytic in nature as suggested by molar conductance measurements. The complexes are adopted to be tetragonal distorted octahedral geometry around the metal ions. The cytotoxic activity of the ligand as well as some of its metal complexes was evaluated against breast cancer (MCF-7). It is worth noting, the cytotoxic activity was enhanced upon complexation. Also, it was interestingly found that, Zn(II) complex (15) recorded the highest IC50 value against MCF-7. However, the other tested complexes showed a weak cytotoxicity against the same cell line compared with a standard drug (vinblastine sulfate).