الفهرس 
Non-alcoholic fatty liver diseaseOnly 14 pages are availabe for public view
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Abstract
Obesity and insulin resistance are known risk factors
for both chronic kidney disease (CKD) and nonalcoholic
fatty liver disease (NAFLD). Further studies identify
mechanisms common to both diseases linked through an
inter-organ communication orchestrated by fetuin-A and
adiponectin.
Fetuin-A, also called Alpha 2-Heremans Schmid
Glycoprotein, is a multifunctional plasma agent that has
been proven in animal and human studies. It plays a role as
a physiological inhibitor of insulin receptor tyrosine kinase
associated with insulin resistance, and non-alcoholic fatty
liver disease (NAFLD).
It also regulates bone remodeling and calcium
metabolism being an important inhibitor of calcium salt
precipitation and vascular calcifications.
Due to secretion of Fetuin-A mainly by the liver, it
may be a marker of liver function and predictor of mortality
in patients with cirrhosis and other complications.
The associations between high Fetuin-A and
metabolic syndrome as well as its hepatic manifestation:
nonalcoholic fatty liver disease (NAFLD) and atherogenic
lipid profile have been well proven. Furthermore, obesity is
a risk factor for chronic kidney disease (CKD) and
nonalcoholic fatty liver disease (NAFLD). Further studies
identify mechanisms common to both diseases linked through an inter organ communication orchestrated by
Fetuin-A and Adiponectin.
The aim of the study, is to determine the serum level
of Fetuin A in cases of non- alcoholic fatty liver disease
(NAFLD), as compared to normal controls.
Also, as a main objective, is to determine the serum
level of Fetuin A in cases of chronic kidney disease (CKD),
as compared to normal controls, and try to correlate it to the
severity of the disease.
Other objectives, is to try to find a relationship
between NAFLD, obesity and CKD, as regards Fetuin A
levels
This is Cross Sectional Cohort Study.
Patients was divided into 4 groups
group I: Includes 20 Healthy adult normal controls.
group II: Includes 20 adult patients with NAFLD.
group III: Includes 20 adult patients with CKD &
NAFLD.
group IV: Includes 20 adult patients with CKD.
All groups are matched as regard age and gender.
All subjects participating in this study had an
informed consent,All studied patients were subjected to Clinical
examination data; History taking data; routine laboratory
tests including liver and kidney tests, electrolytes, lipid and
sugar profiles; Abdominal and pelvic ultrasound studies;
Serum Fetuin A determined by ELIZA technique,
We detected that there is statistically significant
difference between the four studied groups regarding
Weight, Height & BMI (P<0.05). However there is a
statistically insignificant difference between the four
studied groups regarding Age & Gender (P>0.05).
We detected that there is statistically significant
difference between the four studied groups regarding
Serum Feutin-A (P<0.05).
We detected that there is statistically significant
positive correlation between Serum Feutin-A & (Weight,
BMI, Systolic BP, Urea, Creatinine, Sodium, Calcium,
Phosphorous, Cholesterol, Triglyceride, LDL, ALT, AST,
FBS, 2hr PP & RBS); In addition to that there is a
statistically significant negative correlation between Serum
Feutin-A & (Height, HDL & Albumin) (P<0.05).
We detected that there is statistically significant
negative correlation between Serum Feutin-A & (HDL) in
group I ―Adult Normal Controls‖ (P<0.05).
We detected that there is statistically significant
positive correlation between Serum Feutin-A & (FBS); In
addition to that there is a statistically significant negative correlation between Serum Feutin-A & (Diastolic BP)
(P<0.05).
We detected that there is statistically significant
positive correlation between Serum Feutin-A & (FBS), (2
hr PP)(RBS), Serum urea &Creatinine and potassium.; In
addition to that there is a statistically significant negative
correlation between Serum Feutin-A & (Diastolic BP) and
(Systolic BP) (P<0.05).
We detected that there is statistically significant
positive correlation between Serum Feutin-A & (LDL,
Calcium, Triglyceride & Creatinine); In addition to that
there is a statistically significant negative correlation
between Serum Feutin-A & (HR) (P<0.05).