الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Objectives: This study was done to investigate the involvement of apolipoprotein E (APOE) polymorphisms with elevated risk of type 2 diabetes mellitus (T2DM) and obesity. The principal objective of this study is to assess the contribution of APOE polymorphisms (rs429358 and rs7412) with the risk of T2DM and obesity.
Methods: This work was designed involving 400 participants [100 healthy controls, 100 T2DM patients, 100 obese patients, and 100 T2DM+obese patients]. Genomic deoxyribonucleic acid (DNA) of the APOE polymorphisms was characterized using the PCR-RFLP assay.
Results: The common predominant genotype of the study population is the APOE E3/E3 [T2DM patients (46%), obese patients (52%), T2DM+obese patients (37%), and healthy controls (58%)]. The frequencies of the APOE E4/E4 genotype and the APOE*E4 allele were significantly elevated among T2DM patients (p-value < 0.05). Additionally, the frequencies of the APOE E2/E2 genotype and the APOE*E2 allele were significantly increased among obese patients (p-value < 0.05). Moreover, the frequencies of the APOE E2/E2 genotype, APOE*E2 allele, APOE E4/E4 genotype, and APOE*E4 allele were statistically significant among T2DM+obese patients (p-value < 0.05).
Conclusions: APOE*E2 and APOE*E4 alleles were considered as independent risk factors among T2DM+obese patients. Furthermore, the APOE*E2 allele was correlated with elevated risk of obesity, while the APOE*E4 allele was correlated with elevated risk of T2DM.