الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 88 |  |  |
| | | from | 88 | | |
Abstract
Data on the prevalence of Chlamydia trachomatis (C. trachomatis) infection in the Middle East and North Africa (MENA) region remain scarce due to its limited research capacity and sociocultural sensitivity around sexually transmitted infections (STIs). C. trachomatis, an obligate intracellular bacterium, is one of the most common sexually transmitted infections with 89 million new cases thought to occur globally per annum. Infertility affects approximately 5-26% of couples in the reproductive age-group, a figure that is fairly similar between less and more developed countries (9). This figure could, however, rise in the near future as increasing numbers of women delay childbearing, resulting in decreased oocyte quality, raised chance of exposure to sexually transmitted diseases, and a secular decline in sperm counts. C. trachomatis is known to cause damage to the female reproductive tract, primarily due to adhesions or obstructions of the fallopian tubes secondary to the inflammatory response. Reduced chances to achieve an intrauterine pregnancy is the result. Tubal Factor of Infertility (TFI) is the main cause of infertility in 10- 30% of cases in developed countries (13,14) and C. trachomatis is the most common causative agent to PID and TFI in the developed world. We aimed in this study to investigate the possible role of the chlamydial serology as a screening test for tubal infertility, by the detection of the anti-chlamydial IgG antibodies by using E.L.I.S.A. and study the benefit of using non-invasive methods to diagnose chlamydial infection. Patients and methods This prospective randomized clinical study was conducted on a (50) women complaining of Infertility due to Tubal Factor. The patient had been selected from the department of Obstetrics and Gynaecology, Tanta university hospital during the period from January 2019 to January 2020. The patient had been randomly classified into two groups: • group I: including (50) patients complaining primary or secondary infertility. • group II: including (25) patients pregnant and came for Antenatal care. Results Our result showed that serum antichlamydial IgG level was significantly higher among group I (8.62 ±1.4) than group II (2.11±0.82) (p<0.001). Also, 46% of group I had serum antichlamydial IgG positive vs. (12%) in group II with significant difference (p<0.001). Comparing positive Chlamydia trachomatis IgG with type of infertility, a total of 15 (57.7%) of those with primary infertility and 11 (42.3%) of those with secondary infertility tested positive. The difference was of no statistical significance (P=0.725). Conclusion We can conclude that, Chlamydia trachomatis is a major factor in female infertility especially for tubal factor of infertility, serum Chlamydia trachomatis IgG assay could be used a predictive factor for tubal factor infertility.