الفهرس 
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Abstract
This study aims to identify the correlation between the antioxidant status and the extent of oxidative stress in patients with OP insecticide poisoning. The study was conducted on a total number 70 patient divided into two groups. group 1; containing 60 Patients divided to three subgroups (according to the level of poisoning) to mild, moderate and severe groups, and group 2; containing 10 healthy individuals (5 males, 5 females). All were selected from poison control center, Ain Shams University Hospitals. The initial screening of OP poisoning cases was selected with low level of PChE as a reference biomarker for clinical score described by Peradenya Organophosphorous Poisoning (POP) scale. All patients and control were subjected to the following Parameters: Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Zinc (Zn), Vitamin E (Vit E), Vitamin C (Vit C), Malonalaldehyde (MDA), Nitric Oxide (NO), Norepinephrine (NE), Dopamine (DA), Serotonin (5-HT), Aminotransferase (ALT, AST), Albumin (Alb.), Urea, Creatinine (Creat.). Biochemical analysis revealed that OP poisoning caused inhibition of PChE, GPx, CAT, elevation of neurotransmitters MDA, DA, 5-HT, and inhibition of NO. in the other hand there were an increase of Zinc, TAC levels, in addition to impairment of kidney and liver, as evidenced by the abnormal levels of Urea, Creatinine , ALT, AST, Alb. Results showed that OP poisoning induces oxidative stress leading to generation of free radicals, as evidenced by the significant elevated MDA, DA, 5-HT levels, and inhibition of oxygen free radical scavengers; GPx and CAT activity. OPs are very toxic compounds for human, So people should avoid direct contact with OP insecticides products, and there should be a certain restrictions be putted on the sale of these toxic products, and there should be postharvest handling of fresh crops intended for human consumption. iv List of Abbreintion.