الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 121 |  |  |
| | | from | 121 | | |
Abstract
Many cellular, preclinical and observational studies support a role of vitamin D in pathogenesis of TID. VDR locus has been studied in different populations for association with susceptibility to immune-mediated diseases, but with inconsistent findings in TID.
This study aimed to investigate VDR gene polymorphisms in two well characterized genes Fok1 and Bsm1 in children with TIDM in Minia Governorate and compare them with the healthy control.
Thirty children with TID and 20 children age and sex matched healthy control subjects were studied. VDR FokI and Bsm1 polymorphisms were assessed using polymerase chain reaction and restriction fragment length polymorphism (RFLP) analysis.
According to Fok1 genotypes, the diabetic group had significant lower frequency of Fok1 FF and significant higher frequencies of Fok1 Ff , f allele than the control group.
According to Bsm1 genotypes, the diabetic group had significant lower frequency of Bsm 1 BB and significant higher frequencies of Bsm1 Bb , b allele than the control group.
This study demonstrated that VDR gene polymorphisms may be associated with susceptibility to TIDM in Egyptian children in Minia governorate, which Could be explained by differences in VDR FokI and BsmI genotype distributions between T1D and control subjects.