الفهرس 
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Abstract
NDV strains are classified into two distinct classes, I and II Category I viruses consist of a single genotype that typically includes isolated harmless strains of waterfowl and live bird market. Class II viruses are divided into 18 genotypes and multiple genotypes responsible for fatal diseases in poultry..
This study aimed to assess the pathogenicity of two Egyptian strains of NDV of different genotypes in quail based on clinical degrees, overall pathological lesions of organs, histology, and molecular detection of the virus in the organs and expression of virus antibodies. Titer in serum samples. In this study, two-week-old Japanese quails were divided (Coturnix coturnix japonica) were divided into three groups, and quails in groups A and B were experimentally inoculated via the eye and nose pathway with 0.2 ml of 107 EID50 (50%) units of NDV VIb strains (EG/ SR/ 76/ CH/ 1967). And NDV VIId (NDV/ Chicken/ Egypt/ 1/2015) respectively. group C was kept as a control group which received phosphate stock saline solution (PBS).
Regarding to clinical signs, One of( the virus isolates, NDV VIId) was shown to cause only mild clinical signs in addition to no microscopic lesions of the organs, in contrast to NDV VIb and was also not detected in all tissues examined except for only.