الفهرس 
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Abstract
The thesis aimed to investigate the potential role of co-treatment with
doxorubicin (DOX) and verapamil (VRP) or DOX and ginger extract (GE)
nanoparticles in experimentally induced hepatocellular carcinoma in mice and to
investigate the possible mechanisms behind the potential favorable effect of the cotreatment.
Combined treatments with DOX and VRP nanoparticles or DOX and GE
nanoparticles showed superior results versus other treatments. Liver sections from cotreatment
groups revealed absence of necrosis, enhanced apoptosis and nearly normal
hepatic lobule architecture. In conclusion, co-treatment with DOX and VRP
nanoparticles or DOX and GE nanoparticles had enhanced anti-cancer activity and
decreased cardiotoxicity versus the corresponding free forms
EDICATION
This thesis is dedicated to:
My great teacher and messenger, Muhammad (Peace be upon him), who taught us
the purpose of life.
My dear Father for his unconditional support with my studies. I am honored to have
him as my father. I thank him for giving a chance to prove and improve myself
through all my walks of life.
My loving and caring Mother, who has been a source of motivation and strength
during moments of despair and discouragement. Her care and love always give me the
strength to reach my dreams.
My beloved brother and sister, who stand by me when things look bleak.
My beloved small family and my kids Hana and Fares, my sunshine, who brighten
my life with their smile.