الفهرس 
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Abstract
To study the effects of exogenous dietary nucleotides supplementation on broiler performance, gut
health parameters, and immunity. Two separate experiments were performed. The first experiment,
270 one-day-old mixed broiler chicks (Cobb 500) randomly divided into 6 treatment groups with
3 replicates of 15 chicks each. Treatment 1 (CX), a negative control group fed corn-soybean basal
diet without added nucleotides. Treatment 2 (CN 0.05) and treatment 3 (CN 0.1), consisted of
chicks fed a basal diet with the addition of nucleotides on top at two levels (0.05 and 0.1 %)
respectively. Treatment 4 (PX), treatment 5 (PN 0.05), and treatment 6 (PN 0.1) consisted of chicks
that were challenged with C.perfringes inoculum (~ 4×108 CFU/ml) on d 14, 15, 16 and 17of the
experiment and fed diets similar to treatments 1, 2, and 3 respectively. The trial continued for 35
days. The second experiment, a total of 315 one-day-old mixed broiler chicks (Cobb 500) were
randomly assigned to 6 treatment groups with 3 replicates (the number of chick/ replicate differ
according the required stocking density). A 2×3 factorial design with two stocking densities (0.073
m2/ 2.2 kg bird and 0.05 m2/ 2.2 kg bird) and 3 levels of dietary NP (0, 0.05, 0.1 %) was used in
this trial. The trial continued for 35 days. Obtained results showed that dietary nucleotide
supplementation markedly ameliorates the negative effects of stressful condition (such as C.
perfringens infection or high stocking density) by improving the intestinal barrier functions,
intestinal histomorphology, digestive enzymes production, and immune status of bird, which
directly reflected on growth performance of affected birds.