الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Background: Aerosol Delivery With High Flow Oxygen Therapy (HFOT) Is Still Under-Investigation To Be Improved. Issues That Need More Scrutiny Are The Type Of Patient Interface And The Used Gas Flow Rate Especially With Widespread Oxygen Culture As More Is Better. The Present Work Aimed To Evaluate The Impact Of Changing The Interface And The Use Of Titrated Flow On The Delivery Of Inhaled Salbutamol, Pulmonary Function Parameters, And The Overall Tolerability Of Patients.
Methods: The In-Vitro Study Was Conducted Using Aerogen-Solo Nebulizer Placed In The HFOT Circuit where Three Interfaces (Nasal-Cannula, Mouthpiece, And Valved-Facemask) Were Tested At Three Flow Rates Of 10, 20, And 30 L/Min. The Quantity Of Salbutamol Deposited On Each Component Was Measured By High-Performance Liquid chromatography (HPLC). The In-Vivo Procedure Included Forty-Five COPD where All Were Prescribed Inhaled Salbutamol, Delivered By One Of The Three Interfaces With Titrated Oxygen Therapy, And Without It On Different Days. Two Urine Samples Were Collected. Lung Function Parameters Were Measured Pre- And Post-Inhalation.
Results: The In-Vitro Emitted Dose Was The Lowest Significantly With The Nasal Cannula (6.5% Of Nominal Dose When Compared With Other Interfaces At A Flow Rate Of 10 L/Min. The Delivery Of Aerosol Was Decreased With Increasing The Oxygen-Flow Regardless Of The Tested Interface. Regarding The Titrated Oxygen Flow, COPD Patients Showed No Significant Difference Between Mouthpiece And Facemask. But Both Were Significantly Higher Than Nasal Cannula.
Also, The Mouthpiece Showed Significantly The Highest Percentage Of Salbutamol Excreted In Urine 30 Min Post-Inhalation. However, The Valved-Facemask Showed The Significantly Highest Percentage Excreted In Cumulative 24-Hour Samples Than Both Nasal Cannula And Mouthpiece. The Pulmonary Function Results Revealed No Significant Differences Between The Tested Interfaces.
Conclusion: The Current Study Revealed That Salbutamol Delivery Was Enhanced With Both Mouthpiece And Valved-Facemask But The Nasal Cannula Was Still The Most Comfortable Interface. So, These Two Interfaces Can Be Used At Time Of Nebulization To Guarantee Better Pulmonary Delivery. Pulmonary Function Wasn’t Affected By Changing The Interface.
Key Words: Salbutamol, Nasal Cannula, Mouthpiece, Valved Facemask, Pulmonary Bioavailability, HFOT.