الفهرس 
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Abstract
Treatment of chronic periodontitis affected patients is based on
measures for reduction/eradication of periodontal pathogens and
alteration of the systemic and local host susceptibility. It is widely
accepted that, although the bacteria are initiating agents in periodontitis,
the host response to the pathogenic infection is critical to disease
progression. The inflammatory host immune response resulting from
bacterial infection may lead to progressive destruction of the supporting
periodontal structure.
This study aimed to evaluation the effects of topical application of
Simvastatin and Metformin gel as a host response modulator treatment in
management of chronic periodontitis.
This study was conducted on 45 patients with chronic periodontitis.
They were selected from Suez Canal University, faculty of Dentistry outpatient clinic of periodontology department.
They were divided into three groups , each group consisting of 15
patients : group 1 was treated with scaling and root planning and placebo
gel was applied , group 2 was treated with scaling and root planning and
Simvastatin gel was applied , group 3 was treated with scaling and root
planning and Metformin gel was applied .