الفهرس 
ContentsOnly 14 pages are availabe for public view
 |  | from | 99 |  |  |
| | | from | 99 | | |
Abstract
Laryngeal cancer represents 4.5% of all malignancies and 28% of cancers of the upper aerodigestive tract Total laryngectomy continued to have an important role in both the primary and salvage treatment of advanced laryngeal cancer. The incidence of pharyngocutaneous fistula after total laryngectomy is ranging from 9 to 23% in the last decade and remains the most common and serious complication of total laryngectomy The work aimed to study the potential role of PRF in reducing the incidence of pharyngocutaneous fistula after total laryngectomy. The PRF clot forms a strong natural fibrin matrix, which concentrates almost all the platelets and growth factors of the blood harvest and shows a complex architecture as a healing matrix with unique mechanical properties which makes it distinct from other platelet concentrates. This randomized controlled clinical trial was conducted on 67 patients with advanced (T3 and T4) laryngeal carcinoma who underwent total laryngectomy in the Otorhinolaryngology (ORL) Department, Mansoura University Hospitals (MUH), and Egypt. Patients were randomly divided using the closed enveloped method into 2 groups: PRF group (n=35), and control group (n=32). There was a significant difference between groups in the incidence of pharyngocutaneous fistula. It was detected in 2 patients (5.7%) in the study group and in 10 patients (31.3%) in the control group (p=0.004). The application of PRF on the pharyngeal repair after total laryngectomy has a positive effect on healing, decreasing the rate of PCF. Consequently, it decreases postoperative morbidity and hospital stay. It is readily available, cost-effective with no adverse effects or complications.