الفهرس 
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Abstract
Utilization of Wood Industry Wastes for Production of Chemicals and Pharmaceuticals Wastes of wood industry are considered as a burden on the environment due to its huge amount produced annually and not optimally used. It has been found that most of wood industries mainly depend on pine wood that was identified as species Pinus sylvestris L. The family Pinaceae comprises about 10 genera and 166 species. It is widely distributed in the north and south temperate zones and includes the great majority of the living gymnosperms. The family is chemically distinguished by the production of terpenoids, flavonoids, phenols, stilbene derivatives, lignans and others. These compounds have shown various biological activities such as anti-inflammatory, anti-tumor, antioxidant, antibacterial, antifungal, antiviral, and others.The present study includes three chapters: the first chapter comprises a chemical study of different extracts from the remnants of the wood industry of pine plants, the second contains a study of the microbial biotransformation of the main isolated compound and the third includes the evaluation of the anti-toxoplasmosis activity of the isolated compounds.The study aims at exploiting the huge amounts of wastes from wood industry produced yearly to isolate valuable compounds with broad spectrum of pharmaceutical activity; microbial biotransformation of the major isolated compound to decrease its cytotoxicity or increase its biological activity. The metabolite was produced by three microorganisms, Asperigellus ochraceous NRRL 398, A. restricutus NRRL2869 and Rhizopus sp ATCC 36060. So, quantitative analysis was adopted for determination of the concentration of the produced metabolite and its profile of production. In addition, application of the assay of anti-toxoplasmosis activity on these compounds was carried out for the first time through three stages. Introduction: Wood industry waste is a burden on the environment to produce it in large quantities annually and not to being used optimally; It has been found that most of the wood industries depend mainly on pine wood. The pine family consists of about 10 genera and 166 species. The family is chemically distinguished by the production of terpenoids, flavonoids, phenols, stilbene derivatives, lignans and other substances; These compounds have shown different biological activities, such as: anti-inflammatory, anti-tumor, antioxidant, bacterial, fungal, antiviral and others. Aim of work: Exploiting the huge quantities of wood wastes produced annually by isolation of chemical and pharmaceutical compounds and achieving maximum benefit from it by using various techniques such as: microbiological transformation of isolated compounds and measuring the biological activity of the isolated compounds. Material &Methods: 1-Wood wastes (pine sawdust) 2- Glass columns for chromatographic analysis of different extracts of sawdust, thin layers of silica, solvents with different polarities , use of ultraviolet, infrared, 1H-NMR , 13C-NMR in one and two dimensions, and mass spectrometry. 3- Microbiological transformation: components of the fungal media, agar and volumetric flasks. And a fluorimeter device to quantify the produced metabolite. 4- Biological activity against toxoplasmosis and the use of different dyes (giemsa & trypab blue). Results: Isolation of different chemicals and pharmaceuticals, production of a new metabolite from the microbiological transformation of Pinosylvin mono methyl ether, the quantification of the metabolite resulting from three different fungi and identification of the most suitable for the separation and purification of the metabolite without any impurities. It was found that the isolated compounds in addition to the new metabolite have biological activity against T. gondii and are safer on host cells. Discussion: The chemical identity of the isolated compounds and the produced metabolite was confirmed by using ultraviolet radiation, infrared radiation, 1H-NMR , 13C-NMR in one and two dimensions, and mass spectrometry.