الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Investigating the relation between Helicobacter Pylori (H. Pylori) and bladder cancer (BC) can potentially prevent future BC progression. H. Pylori is considered as a class I carcinogen, which is responsible for many disorders as gastritis, duodenal ulcers, gastric adenocarcinoma, also some extra gastrointestinal tract diseases. We aimed to evaluate the relation between H. Pylori infection and BC progression by evaluating H. Pylori antigen in BC patients in comparison with patients with benign bladder diseases and healthy controls. Moreover, we studied the relation between elevated H. Pylori antigen levels and BC patient in terms of ages, sex, BC types and BC stages and grades. A total of 57 BC patients, 54 patients with benign bladder diseases and 75 healthy individuals were included. H. Pylori antigen was detected using western blot and ELISA. In contrast to healthy individuals, sharp band corresponding to H. Pylori antigen (58-kDa) was obtained in sera of patients with bladder diseases who infected with H. Pylori. H. Pylori antigen detection rates increased in BC patients (56.1%) than patients with benign bladder conditions (31.5%). Among BC patients, H. Pylori antigen detection rate was significantly increase (P= 0.023) with the patients ages. According to tumor aggressiveness features, H. Pylori detection rates was significantly higher in late stage than early stage (P =0.007) and higher in high grade compared to those with low grade (P = 0.01). Furthermore, infected people with H. Pylori were more likely to have sever tumor features including late stages and high grades than those without H. Pylori-infection with odd ratio (OR=7.6 and 5.4 respectively) which may indicate that H. Pylori infection increases the risk of disease progression. In conclusion, the result of this study urges oncology physicians, treating BC patients, to consider early detection of H. Pylori among those patients to prevent future tumor progression. Further studies are needed to identify carcinogenesis mechanisms induced by H. Pylori, Specifically bladder carcinoma