الفهرس 
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Abstract
Pasteurellosis is one of rabbit’s most serious bacterial diseases and leads to great financial damages in big production systems worldwide. Increased the efficacy of antibacterial drugs with reduction of their residue is of great importance. Therefore, this study was designed to evaluate the potential role of grape seed extract (GSE) in treating of Pasteurella multocida infection in rabbits, increasing the efficacy of ofloxacin treatment, and reducing of its side effects.
For this purpose, a total of 75 recently weaned male New Zealand rabbits were used. After one week of acclimatization, the rabbits were randomly assigned into five equal groups. On 1st day of the experiment, group I (control group) intranasally administered 0.1 ml sterlilized saline. In all other rabbits, snuffles were induced by intranasal injection of 0.1 ml of P. multocida (1X 107 CFU)
Twenty four hour later (after appearance of clinical signs), various drug regimens were initiated that continued for five consecutive days. Experimentally infected rabbits were allocated into group II (infected–non treated), infected group were orally administered 0.5% DMSO solution; group III (infected-ofloxacin-treated), infected rabbits were orally .