الفهرس | Only 14 pages are availabe for public view |
Abstract Nanocommunication is a significant technology for the interconnection of nanomachines which is exploited for realization nanonetworks concept. This technology aims to design and develop the nano-scale communication capabilities for groundbreaking the applications of medical, industrial and environmental. There are various nanocommunication systems, however molecular communication (MC) is the promising technique for interconnection such nanomachines. One of the forms of molecular communications is the wireless communication based on Forester resonance energy transfer (FRET) phenomenon which is observed among fluorescent molecules. In fact, FRET is a short-range nonradiative energy transfer mechanism between fluorophores, which provides reliable wireless communication mechanism, with highrate to connect fluorophore-based photoactive molecular nanodevices. Various essays have reported that, FRET is significantly employed in a variety of biomedical applications, cell-to-cell interactions, and protein folding/unfolding and enhanced optical bioassays. In a consequence the current thesis focuses on the nanocommunication-based FRET phenomenon. In the current thesis, we present an interdisciplinary survey for nanocommunication technology in various molecular networks; the principles/features of MC and the main comparison with conventional communication schemes are presented. Inspiration by biological cell-to-cell communication, we propose an approach for synesthetic relay transport proteins (RTP)-based facilitative diffusion (FD) in order to facilitate the transmission of therapeutic drug from extracellular environment towards blood vessels through plasma membrane. We actually apply the concept of relay node in the conventional communication to design the molecular networkbased proposed approach. The structure of the molecular nanonetwork consists of three nanomachines-labeled by fluorescent molecule (sensor as transmitter nanomachine, relay nanomachine and actuator nanomachine as receiver nanomachine) to accomplish FRET nanocommunication. Subsequently, we evaluate the performance of the approach in terms of channel capacity and efficiency of information transfer. We also perform a performance comparison of molecular nanonetwork with and without the proposed RTP. On the other hand, Internet of Biological Nano Thing (IoBNT) is a novel paradigm that is emerged in a similar manner of IoT. We propose a molecular communication (MolCom) system can be jointed with IoBNT paradigm in order to interconnect a macroscale network (i.e., Internet cyber domain) with nanonetwork (i.e., biological intra-human body). We design a feasible downlink/uplink biocyber interface for this paradigm. In the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intra-body nanonetwork. In the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system-based FRET while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of successful probability of drug delivery, channel capacity, average drug-delivery time, and throughput. The simulation results show that V the proposed IoBNT is a promising paradigm for smart drug delivery system and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork. |