الفهرس 
Introduction &Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Antitumor Effect of Polydatin and Rutin in Experimentally Induced Hepatocellular Carcinoma. Hepatocellular carcinoma (HCC) remains the 3rd principal cause of cancer-induced deaths in the world. Egypt has a record of the world’s highest HCV prevalence; where it causes more than of 90% of HCC-cases. Rutin (RUT) and Polydatin (PD) are naturally occurring glycosides that have been reported to have anti-tumor effects, they inhibit cell proliferation, invasion, and migration. In this study, hepatoprotective effects of RUT, PD and their combination in thioacetamide (TAA) induced HCC rat model were investigated. It also aimed to assess the effect of RUT and PD on cisplatin (CP) anti-tumor activity and nephrotoxicity. Morevere, RUT and PD have shown promising protective effects through several mechanisms: (1) Increased activity of the antioxidant defensive system, (2) Down regulation of B-catenin and Cyclin D1 at the gene and protein levels, (3) Induction of apoptosis via up-regulation of Caspase-3 gene, apoptotic BAX protein expression levels and down-regulation of anti-apoptotic BCL-2 protein expression levels in hepatocytes. Remarkably, the RUT+PD combination significantly showed superior cancer protective activity, greater than each group separately. It reached a comparable outcome to negative control group. RUT and PD can be used as supportive and/or complementary approach in treatment of HCC. Further clinical investigations are recommended before implementation of these agents in cancer regimens.