الفهرس 
Auditory Neuropathy Spectrum Disorder (ANSD)Only 14 pages are availabe for public view
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Abstract
Background: Cochlear implantation (CI) is now recognized as the most possible approach to help ANSD patients in improving their capability in hearing and speech communication.Because there are no reliable methods in clinical practice to identify the exact lesion site and mechanisms for a certain ANSD patient, the efficacy of CI is difficult to predict before surgery.
Objectives: To study speech ABR and CAEP P1 in ANSD subjects fitted with CIs and to compare results of both tests in ANSD versus SNHL subjects fitted with unilateral CIs.
Subjects and method: The current study was conducted on a total number of 45 subjects who were classified into three groups (one control and two study groups). The control group comprised 16 subjects with normal peripheral hearing sensitivity. The study group comprised 29 children who underwent cochlear implantation. They were subjected to detailed history taking, aided warble-tone sound field audiometry, Speech-evoked potentials (P1 & ABR) and Questionnaire.
Results: There were statistically significant differences between the control group and both study subgroups regarding the P1 latencies. While; there were no statistically significant differences between {SNHL group &ANSD}. C-ABR waves were detected in 100% of control group, 75% of SNHL group and 53.8% of ANSD group. Sound-field S-ABR measured in the CI recipients indicated statistically significant delayed latencies, than in the NH group. In addition, these results demonstrated that the frequency following response peak amplitude was significantly higher in CI recipients, than in the NH counterparts. Finally, the neural phase locking was significantly higher in CI recipients due to electrical artifact.
Conclusions:
• There were no statistically significant differences between normal and both cochlear implant cases either with SNHL or ANSD regarding P1 latency.
• C-ABR waves were detected in 75% of SNHL group and 53.8% of ANSD group with delayed latencies and higher amplitude than control group. The findings of sound-field S-ABR demonstratedthat CI recipients have neural encoding deficits in temporal and spectral domains atthe brainstem level; therefore, the sound-field S-ABR can be considered an efficient clinical procedure to assess the speech processing in CI recipients.