الفهرس 
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Abstract
Study of Genetic Polymorphisms of Vascular Endothelial Growth Factor in Women with Recurrent Abortion
Recurrent abortion is defined as the loss of a fetus prior to 20 weeks of gestation Approximately 1~5% of clinically recognized pregnancies are spontaneously aborted.
There many causes lead to recurrent abortion such as: endocrine or hormonal problems, coagulation protein defects, nutritional, environmental factors and the major cause is fetal chromosomal abnormalities.
Vascular endothelial growth factor (VEGF) induces endothelial cell proliferation and migration, enhances vascular permeability, reduces endothelial cell apoptosis and promotes stromal proteolysis.
The aim of this study is to test for the association of the endothelial growth factor (VEGF) gene including C2578A, G1154A, C634G and C936T polymorphisms with recurrent abortion among Egyptian women. The relation between these genetic variants will be also tested with different demographic and clinical characteristics of cases.
The study participants included 100 female cases with a history of 2 or more events of recurrent abortion.
These cases were compared to other 100 subjects who were clinically healthy unrelated women with at least one previous uneventful pregnancy, taken as a control group.
The result of this study in conclusion, recurrent abortion among Egyptian women was strongly associated with the mutations related to VEGF gene polymorphism. characteristically, these cases showed high frequencies of VEGF C2578A, G1154A, and C634G mutation. Interestingly, VEGF C2578A, G1154A, and C634G mutation frequencies were relatively higher among cases with recurrent abortion than VEGF C936T.
For this reason we have to recommend,
• Routine screening for recurrent abortion mutations for all Egyptian pregnant women in order to setup an appropriate method of prophylaxis against recurrent abortion disorder.
• Population screening for VEGF C2578A, G1154A, and C634G carriers for detection of susceptible individuals to whom adequate programs can be implemented to prevent recurrent abortion.