الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Choroidal neovascularization is an important cause of visual loss in patients with age-related macular degeneration. For long time, fluorescein angiography was considered the gold standard diagnostic modality for diagnosing choroidal neovascularization. However, it is an invasive modality that require injection of dye that may be associated with serious adverse events. Optical coherence tomography angiography is a novel, rapid, noninvasive diagnostic modality that avoid the hazards associated with FA making it suitable for following-up CNV in each visit. We studied the response of choroidal neovascularization to anti- VEGF therapy using optical coherence tomography angiography and evaluated various biomarkers including mean area of CNV, flow area inside CNV, total length of CNV vessels and the number of segments of vessel inside the CNV. We found that all these parameters deceased significantly all over the course of treatment and reduction of these parameters was significantly correlated with reduction of retinal thickness along the course of treatment with anti-VEGF therapy. In addition, we found that the morphological pattern of the CNV was correlated with the activity of the CNV. The morphological patterns of active lesion included sea-fan and lacywheel pattern with numerous fine branching anastomotic vessels associated with peripheral arcades and perilesional hypointense halo. The morphological pattern of the inactive lesion was characterized by reduction of the fine branching anastomotic vessels, reduction of peripheral arcades and dead tree morphology.