الفهرس 
N EPHROTIC S YNDROMEOnly 14 pages are availabe for public view
 |  | from | 160 |  |  |
| | | from | 160 | | |
Abstract
Background: Nephrotic syndrome characterized by proteinuria, hypoalbuminemia and generalized edema is one of the most common chronic kidney diseases encountered during childhood. It can be idiopathic or provoked by systemic diseases (eg, diabetes mellitus, systemic lupus erythematosus, amyloidosis, and cancer), drugs and infections.
Objective: To determine if cognitive, behavioral and psychosocial problems are important correlates of childhood idiopathic nephrotic syndrome.
Subjects and Methods: We conducted a prospective, repeated-measure cross over study in which (60) children from the pediatric nephrology clinic, Ain Shams University were studied. Our studied patients were divided into 3 main groups. group 1 included 20 children with steroid sensitive nephrotic syndrome (SSNS) with infrequent relapses, group 2 included 20 patients with steroid dependent nephrotic syndrome(SDNS), patients with frequent relapses and patients with steroid resistant nephrotic syndrome and group 3 included 20 SDNS patients frequent relapses and SRNS patients who were recieving immunosuppressives eg. (cyclosporin A, Mycophenolate moletil and Tacrolimus) other than steroids plus or minus low dose alternate day steroid treatment.
Results: In our study we found a significant difference between the males and the females as regards IQ. Females had a higher IQ than males but there was no significant difference between the males and the females as regards depression, anxiety and CBCL. In our present study we found the correlation between the duration of steroid therapy and the depression at baseline& follow up is statistically significant.
Conclusion: We can conclude that we found significant results during our study concerning the effects of childhood NS on behavioral and psychosocial aspects of these children. Positive results of behavioral/psychological abnormalities reported in cases when studied at baseline (in comparison with controls) can reflect the effect of the disease itself and may also refer to effects of previous courses of high dose corticosteroids