الفهرس 
Psoriasis:Only 14 pages are availabe for public view
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Abstract
Psoriasis is a common inflammatory skin disease, taking a chronic recurrent course. chronic plaque psoriasis (psoriasis vulgaris) is the most common form. The typical lesions are monomorphic and well-demarcated erythematous plaques covered by silvery lamellar scales.
Psoriasis prevalence varies in different populations, ranging from 0.91–8.5% of the world’s population. Psoriasis is considered a multifactorial disorder in which systemic inflammation is widespread.
Although the pathogenesis of psoriasis is not fully understood, evidences of endothelial dysfunction, hyperocoagulable state and systemic inflammation, have been reported in psoriasis.
Von Willebrand factor is an adhesive glycoprotein that circulates in plasma in large multimers. It is synthesized by endothelial cells and bone marrow megakaryocytes and subendothelial connective tissue. It is released through a well regulated pathway. It is stored in endothelial cells Weibel-Palade bodies and platelets alfa granules.
Von Willebrand factor plays a central role in primary hemostasis as it mediates adhesion of platelets to the subendothelium at sites of vascular damage, also, it is the carrier and the stabilizer of circulating factor VIII.
Von Willebrand factor is considered as a marker of endothelial dysfunction and injury. von Willebrand factor is considered an acute-phase reactant that increases in inflammation and vasculitis. Besides its role in thrombus formation, vWF may represent a possible ―connection bridge‖ between the hemostatic and the inflammatory pathway. It supports leukocyte and platelet recruitment , rolling, adhesion and extravasation in inflammed tissue. It also modulates vascular permeability and edema formation, may promote atherosclerotic plaque formation and inflammation, and provides an activating surface for complement activation. Elevated level of this factor is associated with increased cardiovascular risk and has been found in patients with various Immune Mediated Inflammatory Diseases (IMIDs) such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.
Therefore, the aim of this study was to investigate the von Willebrand factor serum level as an inflammatory and thrombotic marker in patients with psoriasis compared to healthy subjects and to study the correlation between this evaluated serum vWF level and the clinical aspects (severity, duration and age of onset) of psoriasis.
To elucidate our aim, This study was conducted on 36 patients with psoriasis vulgaris with variable degrees of severity and 36 healthy volunteers of matched age and sex as acontrol group. Cases were selected from Dermatology outpatient clinic, Faculty of Medicine, Menoufia University Hospital, all patients were subjected to complete history taking, clinical general and dermatological examination, including assessment of psoriasis severity by PASI score and vWF serum level estimation by ELISA.
The patients age ranged from 15 to 55 years, with a mean value of (41.2±10.1). Patients were 21 male (58.3%) and 15 female (41.7%). Regarding the onset of the disease 25% of cases had early onset of the disease and 75% had late onset. Sixty-six point seven of cases had progressive course, 5.6% had been complained from remission and relapse and 27.8% had stationary.