الفهرس 
Acquired Aplastic AnemiasOnly 14 pages are availabe for public view
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Abstract
Summary Aplastic anemia (AA) is a rare disease which characterized by pancytopenia and an acellular or markedly hypocellular bone marrow. AA can be idiopathic, inherited or secondary to radiation, drugs, viruses or immune disorders. Idiopathic and secondary AA are usually immunemediated by autoreactive lymphocytes mediating destruction of hematopoietic stem cells. Aplastic anemia can range from mild to severe .Severe aplastic anemia where bone marrow cellularity <25% or cellularity <50% with <30% residual hematopoietic cells with at least 2 among the following ;Absolute reticulocyte count <20 × 109/L (<60 × 109/L using an automated - analysis),platelet count <20 × 109/L, and absolute neutrophil count <0.5 × 109/L ,Very severe aplastic anemia where absolute neutrophil count <0.2 × 109/L and fulfills rest of the criteria for severe AA ,and Non- severe aplastic anemia where bone marrow cellularity> 25% with peripheral blood values not meeting the criteria of sever aplastic anemia. IL8 is a chemokine produced by macrophages and other cell types as epithelial cells, airway smooth muscle and endothelial cells.IL8 induces chemotaxis in target cells, IL-8 is also produced by numerous types of cells including macrophages, neutrophils, T cells, fibroblasts, etc. They are critical for tissue damage in acute inflammation and have been shown to be potent inhibitors of myelopoiesis. Interleukin promotes macrophages to produced IL 8 in aplastic anemia. Aplastic anemia patients showed an elevated level of IL 8 which produced by macrophages. They also showed an elevated expression of IL 17A mRNA in bone marrow mononuclear cells and peripheral blood