الفهرس 
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Abstract
The present study aims to investigate a potential renoprotective effect of gum acacia (GA) against diclofenac (DICF) induced acute renal injury in rats. Six groups of rats were used: Normal group; Control group (deprived from water during week 13), DICF group (deprived from water during week 13 and injected DICF i.p. 15 mg/kg/12 hours at days 4 through 6 of water deprivation days, GA groups (1, 2 or 3 g/kg/day in drinking water) for 12 weeks followed by water deprivation and DICF injection as described. Administration of DICF along with water deprivation induced kidney injury indicated by high levels of kidney function biomarkers including creatinine, urea and uric acid. Besides, DICF resulted in oxidative stress generation indicated by an increase in renal tissue MDA level and decrease in the GSH, catalase and TAC level. Diclofenac also showed a marked elevation in TNF-α, caspase-3, IL-1β and MCP-1 levels and decrease in CR-1 level.Administration of GA for 12 weeks before DICF attenuated DICF induced renal injury. Gum acacia obviously reserved normal levels of renal function biomarkers serum (creatinine, urea and uric acid) levels. It also activated endogenous antioxidant enzymes (catalase and GSH), elevated total antioxidant content and reduced lipid peroxidation (low MDA level).