الفهرس 
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Abstract
Cognitive impairment is a common comorbidity often seen in epileptic children; this comorbidity is negatively affecting their quality of life. Cognitive comorbidities are often attributed to seizures, structural brain malformation and antiepileptic drugs (AEDs); furthermore the AEDs increase the risk of dyslipidemias and cerebrovascular diseases which may predispose also to cognitive impairment.
This study was designed to assess the impact of epilepsy and antiepileptic drugs on cognitive function of epileptic children and to compare the effect of old and new generation antiepileptic drugs on cognitive function and lipid profile.
This study was carried out on 80 children their age range (7-16) years admitted to the pediatric department or visit pediatric neuropsychiatric clinic of Minia University Hospital for Children in the period from (August 2018 to April 2019)
The participants were divided into 4groups:
group I: Included 20 children served as healthy control for the studied epileptic patients, the mean age of children was (9.8±2.7) years.
group II: included 20 newly diagnosed epileptic children didn’t receive antiepileptic drugs until the time of study; the mean age of children was (10.8±2.1).
group III: included 20 epileptic children previously diagnosed and treated with old antiepileptic drugs, while the duration of treatment was more than 2 months and the mean age of children was (9.3±2) years.
group IV: Included 20 epileptic children previously diagnosed and treated with new antiepileptic drugs ,while the duration of treatment was more than 2 months, the mean age of children was ( 11 ±2.9) years.
from this study we concluded that:
1-The epileptic children have a higher risk of dyslipidemias; epileptic patients treated with AEDs (old &new) have higher serum level of TC&LDL than other groups and epileptic patients treated with old generation AEDs had higher serum VLDL &TG; While higher LDL was also detected in untreated newly diagnosed epileptic children, on the other hand higher HDL levels were detected in patients treated with new AEDs than other groups.
2-Global cognitive impairments (low total MOCA-B & its factors, low total SB5th edition IQ & its factors and prolonged latencies of ERP p300 at FZ, CZ, and PZ) were observed in epileptic patients treated with old AEDs.
Also there is mild cognitive impairments were detected in newly diagnosed epileptic children ( low total MOCA ,low attention score mainly , low SB5th &its factors ,and prolonged latency of p300 at CZ ) when compared to controls
3- A neutral effect of new AEDs on cognitive function was found measured by (total MOCA-B and its factors &total SB5th IQ and its factors) , while positive effect of the same drugs(new generation) was detected by p300 ERP ,which is more sensitive (in the form of shorter latencies of P300 at FZ,CZ, and higher p300 amplitude at CZ ).
4- Significant negative correlation between some of lipid profile (TG, TC and VLDL) and cognitive function was observed in all epileptic patients, while LDL has a significant week negative correlation with SB5th non –verbal IQ and total IQ only. On the other hand HDL has a positive insignificant correlation with cognitive function.
5-The inter-ictal EEG changes has insignificant correlation with the cognitive function ,while the insignificant lowest scores of cognitive function were observed in generalized IED, and insignificant highest scores cognitive function were observed in normal inter-ictal EEG of epileptic children.
6- Finally the educational level was positive correlated with total MOCA-B in epileptic patients and we concluded that the education serve as a brain reserve for cognitive function of epileptic children.