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Abstract SUMMARY ifferent models of comorbidity are generally proposed to link different psychiatric illnesses to SUD. Psychiatric disorders may be considered as a risk factor for SUD or substances of abuse may be used as a selfmedication to reduce symptoms of the psychiatric disorder. Relation between ADHD and substance use have been proposed, ADHD may be considered as a risk factor for SUD. Common genetic background for both ADHD and SUD plays also a contributing factor. The presence of adult ADHD among patients with SUD was associated with a more complicated course of SUDs and severe dependence on cigarette, number of relapses and number of hospitalization and had poor SUD treatment prognosis Impulsivity and consequent risk-taking are associated with both substance use disorder and ADHD. Impulsivity is a core diagnostic feature of the hyperactive-impulsive and combined presentations of ADHD and may be a determining factor in the initiation and maintenance of substance use, with increased levels of impulsivity consistently found among those with SUDs. Accordingly, increased risk-taking is observed among both SUD and ADHD populations. D Summary 107 This study was conducted aiming to investigate the association between the prevalence and severity of drug abuse and co-occuring ADHD symptoms and to examine related risk behaviors in females seeking treatment for SUD with co occuring symptoms of ADHD. The total number of participants was 30 female participants with diagnosis of SUD (15 with ADHD symptoms). All of them were located in Cairo. The study was conducted at Abbasya mental health hospital from inpatients ward during a period of nearly one year starting on September 2017 till July 2018. All participants aged from 21 to 40 years old with single or multiple substance use, patients with more than 15 days of abstinence were included in the study after their consent. Patients with any other psychiatric disorder other than SUD were excluded. All subjects of the study were assessed by using Structured Clinical Interview for DSM-IV diagnostic tool to diagnose SUD and exclude other Axis I diagnosis, also Addiction severity index to address potential problem areas in substance-abuse. The Arabic-translated and validated version of the adult ADHD Self-Report Scale Symptom Checklist was used for screening for adult ADHD symptoms, the Barratt Impulsiveness Scale Version 11 and the Arabic version of Summary 108 hostility and aggression scale for adults were used to assess risk behaviors. History taking was obtained according to the semistructured psychiatric interview with sexual history to assess sexual risk behaviors. Results of this study revealed that: The mean age of the patients sample was 23.6 ± 2.6 years. As regard the marital status, 15 were single (50%), 11 were married (36.7%) and 4 were divorced (13.3%). Those with family history of substance use disorder were 16.7% while 10% had family history of ADHD, mood disorder were 16.7%. And there is no statistically significant difference regarding family history. Regarding the type of substance abuse, most of the patients abused poly substances, 83.3% were abusing cannabinoids, 80% were abusing alcohol, 50% were abusing opiates, 23.3% were abusing pregabline, 30% were abusing tramadol and 16.7% were abusing synthetic cannabinoids with no statistically significant difference concerning the substance of abuse between SUD patients with ADHD symptoms group and SUD patients without ADHD symptoms group except for synthetic cannabinoids which SUD patients with ADHD symptoms group abused and difference was statistically approaching significance. Summary 109 Regarding the mean age of onset of substance use was 15.5 ± 2.6 years old, the mean age of onset of smoking was 13.5 ± 3 years old. There is statistically significance supporting that SUD patients with ADHD symptoms group start smoking (nicotine use) and substance use at earlier age than SUD patients without ADHD symptoms group. Forty percent have considerable severity on addiction severity index total score, 33.3% have extreme severity, 20% have mild severity and 6.7% have slight severity and not problematic enough to affect their life socially or financially with no statistically significance between SUD patients with ADHD symptoms group and SUD patients without ADHD symptoms group. Forty percent of the study sample had slight health problems. Regarding employment and support status, 53.3% had considerable problems affecting their work and financial situation. As regard drug and alcohol abuse and relapse, 40% had considerable problems related to daily doses of substance use, hospital admission and trials of abstinence and relapses. While regarding legal status, forty percent has mild problems regarding doing illegal activities for profit (sex trading, selling stolen gods, stealing) and regarding the family and social relationships, forty percent has considerable problems with family and friends affecting the quality of the relationship. Summary 110 Comparison between SUD patients with ADHD symptoms group and SUD patients without ADHD symptoms group there is statically significance regarding employment and financial support and employment and social status as measured by addiction severity index. Regarding Barrett impulsivity scale, 73.3% were severely impulsive and 26.7% were moderately impulsive and there is no statistically significance between the two groups. Comparison between SUD patients with ADHD symptoms group and SUD patients without ADHD symptoms group using aggressive and hostility scale, there is no statistically significance although it was found that about half of the sample of patients had moderate physical aggression and verbal aggression (43.3%, 63.3%). Regarding Anger, most of the patients had moderate (40%) to severe anger (56.7%). On the other hand, most of the patient had no (50%) or mild (46.6%) hostility. The mean age of first sexual activity was 16.8 ± 2.1 years and the number of sexual partners from first sexual activity till the time of the study is 3 ± 2-5 partners. And there is statistically significant increase towards SUD patients with ADHD symptoms group who started their sexual activity at earlier age of 15.7 years and has mean number of 5 sexual partners. Therefore all adults with ADHD should be systematically queried for SUD and vice versa. Evaluation and Summary 111 treatment of comorbid ADHD and SUD should be part of a plan in which consideration is given to all aspects of the adult’s life. Any intervention in this group should follow a careful evaluation of the patient, including psychiatric, addiction, sexual, social, cognitive, educational and family evaluations |