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Abstract The anal fistula is a chronic inflammatory process that does not heal spontaneously and surgery remains the elective treatment. The cryptoglandular hypothesis states that infection of the anal glands associated with the anal crypts is the primary cause of anal fistula. The aim of the work is to evaluate success rate of ligation of intersphincteric fistula tract (LIFT) operation in the treatment of simple anal fistula. This study was submitted on 30 patients. 20 (66.7%) were male and 10 (33.3%) were female. The age Mean ± SD is 42.1±18.6 years. Complaining of cryptoglandular, simple transsphicteric anal fistula and all treated by (LIFT) operation. In our study we found that the operative time ranging between (35-40 min), Mean±SD=38.0±2.54. Severity of post-operative pain was assessed on a scale of 0 to10 with the help of the Visual Analogue Scale (VAS). The VAS Mean±SD is 3.3±1.4. Subsidence of pain (VAS score < 1) was noted at about three weeks. In this series of cases, a primary healing rate of 80% (24 patients) was observed and the recurrence rate was 20% (6 patients). The follow up in this series was 6 months. patients who did not achieve a primary healing in this study, all showed recurrence in the incision for ligation of the fistulous tract, i.e., their defects turned into intersphincteric fistulas, and could be subsequently treated by fistulotomy with complete resolution and with no fecal incontinenc |