الفهرس | Only 14 pages are availabe for public view |
Abstract Heart failure (HF) is a major health problem because it is common, and has a high rate of hospitalization and high rate of mortality. While substantial advances have been achieved in the treatment of heart failure over the past two decades, HF mortality remains as high as cancer mortality. Coronary artery disease (CAD) remains the main cause of HF. The aim of this study. To investigate the association between serum GDF-15 and chronic HF due to CAD, and its potential usefulness as a biomarker in these patients. Methodology This study was conducted on A total of seventy nine patients at Fayoum University hospitals and was classified as : Fifty patients having the typical symptoms and signs of heart failure and diagnosed with either heart failure with reduced ejection fraction (HFrEF) or heart failure with preserved ejection fraction (HFpEF). Twenty nine patients as control group. Blood samples for GDF-15 level were analyzed. The results demonstrated significant relation between elevated GDF-15 levels and HF patients due to coronary artery disease in comparison to patients with no HF in the control group. A significant relation between elevated GDF-15 levels and worse functional status of the patients represented by NYHA class Conclusion: Our results suggest that GDF15 could be an independent marker for diagnosis, and management of patients with heart failure caused by CAD. |