الفهرس 
Introduction and RationaleOnly 14 pages are availabe for public view
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Abstract
Prescription drug abuse is an increasing problem and has reached an epidemic level in some countries. Currently PGB is considered as one of the most abused anti-epileptic drugs worldwide and it has been proved that PGB induces addictive behaviors. It is widely used as analgesic in treatment of neurogenic pains of chronic diseases, especially diabetic neuropathy.
Pregabalin was first emerged in the UK mortality databases in 2006.14 In Egypt, the poisoning control center of Ain Shames hospitals reported that 71 patients were intoxicated by PGB during year 2018 compared with only six patients in 2017.19 In 2015, the emergency toxicology unit in Mansoura University conducted a study on patients with disturbed level of consciousness with no history of drug abuse. Pregabalin was detected in 60 % of urine samples of 120 patients.20
The present study aimed to identify the probable changes in brain, heart, liver and kidney attributable to PGB administration in both acute and chronic toxicity in adult albino rats. The study included 96 male and female adult albino rats weighing 100-150 g. Rats were divided into 3 main groups:
group I: Rats received 1 ml/ kg daily normal saline (0.9% NaCl) and served as normal control groups.
group II: Rats received one PGB LD50 dose (5000 mg/kg) for one day and served as acute intoxicated group.
group IIIA: Rats received PGB (500 and 1000 mg/kg, orally; daily representing 1/10 and 1/5 LD 50, respectively) and served as 6 weeks chronic intoxicated group.
group IIIB: Rats received PGB (500 and 1000 mg/kg, orally; daily representing 1/10 and 1/5 LD 50, respectively) and served as 12 weeks chronic intoxicated group.
Ethical approval from research ethics committee, in Faculty of Medicine, Suez Canal University was obtained before beginning of the study.