الفهرس 
Signs and symptoms of diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
The present work aimed to study the effect of either vitamin D or coconut oil or both together on the physiological parameters and histological and IHC changes of the liver and kidney tissues of STZdiabetic rats. Experimental design Seventy male rats were equally divided into seven groups as follows: group Ι: control rats injected daily with 0.1 ml diluent solution. group ΙΙ: non-diabetic rats administered orally with coconut oil at a dose of (7.5ml/b.w/d) for 30 days. group ΙΙΙ: non-diabetic rats given Vitamin D orally at a dose of (500IU/b.w/d) for 30 days. group ΙV: STZ-diabetic rats injected i.p. (served as hyperglycemic group, positive control group). group V: diabetic rats given coconut oil orally at a dose of (7.5ml/b.w/d) for 30 days. group VΙ: diabetic rats administrated with vitamin D orally at a dose of (500IU/b.w/d) for 30 days. group VΙ: diabetic rats co-administrated orally with coconut oil and vitamin D. At the end of 30 days of the experiment, rats were fasted for 14 hours and then sacrificed, kidney and liver tissue samples were carefully dissected out and divided into pieces for biochemical, histological and IHC studies. The results obtained could be summarized as follows: A) Physiological & Biochemical measurements: Diabetic rats recorded a significant increase of blood glucose value compared with normal control ones. The non-diabetic rats given either vitamin D or coconut oil at a dose (7.5 mg/kg/b.w or 500IU/kg/b.w, respectively) for 30 days recorded non-significant decrease of blood glucose value compared with the control normal rats. Administration of both vitamin D and coconut oil together to diabetic rats recorded high significant decrement of blood glucose values for 30 days than those taken vitamin D alone or coconut oil alone. Diabetic rats recorded significant decline in serum C-peptide compared to the normal control rats. Either vitamin D or coconut oil given to non-diabetic rats caused non-significant increase in serum C-peptide levels compared to control group. The diabetic rats given vitamin D or coconut oil or both together recorded highly significant increase of serum C-peptide values specially both together compared to the diabetic rats. Diabetic rats recorded significant decline in body weight compared to the normal control rats. Either vitamin D or coconut oil given to nondiabetic rats caused the decrease of body weight gain compared to control group. The diabetic rats given vitamin D or coconut oil or both together recorded highly significant increase of body weight gain specially both together compared to the diabetic rats. Diabetic rats recorded significant decline in serum α amylase compared to the normal control rats. The vitamin D and coconut oil given to non-diabetic rats caused insignificant increase in serum α amylase levels compared to control group. The diabetic rats given vitamin D or/and coconut oil caused highly significant increase of serum α amylase values specially both together as compared to the diabetic rats group. Diabetic rats recorded significant decrease in serum albumin compared to the normal control. The vitamin D and coconut oil given to non-diabetic rats caused insignificant decrease in serum albumin levels compared to control group. The diabetic rats given vitamin D or/and coconut oil caused highly significant increase of serum albumin values specially both together as compared to the diabetic rats group. Diabetic rats detected significant increase in serum ALT and AST compared to the normal control ones. The vitamin D and coconut oil given to non-diabetic rats caused insignificant decrease in serum ALT and AST levels compared to control group. The diabetic rats given vitamin D, coconut oil or both together caused highly significant decrease of serum ALT and AST values specially both together as compared to the diabetic rats group. Diabetic rats detected significant decrease in serum total protein compared to the normal control rats. Diabetic rats given coconut oil recorded insignificant increase of total protein contents in serum. While the diabetic rats administrated with vitamin D or/and coconut oil recorded high significant increase of total protein contents in serum specially both together. Diabetic rats recorded significant increase in serum urea and creatinine compared to the normal control. The vitamin D and coconut oil given to non-diabetic rats caused insignificant decrease in serum urea and creatinine levels compared to control group. Diabetic rats administrated with vitamin D or coconut oil or both together caused high significant decrease of serum urea and creatinine compared to diabetic rats group. Also, diabetic rats recorded significant increase in serum total cholesterol and triglycerides compared to the normal control ones. The vitamin D and coconut oil given to non-diabetic rats caused insignificant decrease in serum total cholesterol and triglycerides compared to control non-diabetic group. Diabetic rats administrated with vitamin D or coconut oil or both together caused high significant decrease of serum total cholesterol specially both together compared with diabetic rats group. Diabetic rats illustrated significant decrease in SOD, CAT, GPX and GSH compared to the normal control rats. The vitamin D and coconut oil given to non-diabetic rats caused insignificant increase in SOD, CAT, GPX and GSH compared to control non-diabetic group. The diabetic rats given vitamin D or coconut oil or both together caused high significant increase of SOD, CAT, GPX and GSH specially both together compared with diabetic rats group.