الفهرس 
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Abstract
Urginea maritima, which is one of plants that grows in North Sinai and has medicinal uses were studied for its toxic effect on albino rats. Twenty four albino rats weighing 100 gm were divided into 4 groups, the 1st group consists of six male rats and the 2nd group consists of six female rats were given di-methyl sulfoxide orally for 45 successive days and they considered as control group. The 3rd group contained six male rats were given 36 mg/kg body weight (1/20 LD50 from alcoholic extract of Urginea maritima) for 45 successive days. The 4th group of six female rats were given 26 mg/kg body weight (1/20 LD50 from alcoholic extract of Urginea maritima) for 45 successive days. At the end of the experiment, serum samples were collected for biochemical analysis and samples from heart, brain and sciatic nerve were taken for histopathological examination. The result showed significant changes in the serum level of sodium, potassium and calcium of exposed animals to the plant extract. Serum sodium and calcium levels were significantly decreased, while serum potassium level was significantly increased. There was also significant increase in creatine kinase and lactic acid dehydrogenase activities. At the same time, there was no changes recorded in liver and kidney function showed no changes compared to control. However, pathological changes were found in the heart, brain and sciatic nerve compared to control.