الفهرس | Only 14 pages are availabe for public view |
Abstract In this prospective single blind study conducted on 75 patients undergoing elective surgery, we tried to evaluate the effect of the magnesium sulphate on the onset time, duration, train of four ratio, hemodynamics and intubating conditions of Rocuronium bromide. The summary of our findings are the excellent intubating condition was more frequent in the magnesium group compared to the other groups,onset of neuromuscular block was shorter in the magnesium group than in the control and ketamine groups Magnesium sulphate didn’t significantly prolong rocuronium duration compared with the control. This may be because the magnesium dose (50 mg/kg) may have been too small to increase rocuronium duration Magnesium attenuates catecholamine release and elevation of blood pressure after intubation. Although mean arterial pressure tended to be lower in the magnesium group,it was not statistically different among the groups in this study.this may be partially attributed to fentanyl, which may have blunted cardiovascular changes in all groups. Ketamine neither improved intubating condition nor accelerated rocuronium onset when compared with the control group.it was postulated that increased cardiac output and blood pressure by ketamine would facilitate rocuronium delivery to the relevant neuromuscular cleft, leading to a faster neuromuscular block. |