الفهرس 
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Abstract
Acrochordons, also known as skin tags (STs) or soft fibromas, are common, small, soft, usually pedunculated benign skin tumors that are most often found on the neck, axilla or groin. They are protrusions of the loose fibrous tissue.
Insulin like growth factor-1 is a protein that in humans is encoded by the IGF1 gene, which is located on the long (q) arm of chromosome 12 at position 23.2.
The current study aimed to investigate insulin like growth factor-1 immunohistochemical tissue expression and its gene polymorphism in patients complaining of skin tags.
This case-control study was carried out on 60 subjects. They were 40 patients having skin tags (patient group) and 20 age and sex matched apparently normal subjects (control group).
This study aimed to analyze the role of IGF-I gene polymorphisms including CA (19) polymorphism using conventional PCR, Rs6214 polymorphism using real time PCR and also the tissue expression of IGF-1 in excised ST lesions using immunohistochemical technique.
IGF-1 immunoreactivity showed significantly strong up regulation in epidermis, as well as in dermis, especially in endothelial cells of excised STs than control skin.
TT and CT rs6214 genotypes and its T allele were significantly associated with STs. Also, (<192 bp) and 192-194 bp (CA) 19 genotypes were significantly predominant in STs patients than controls. All these genotypes were significantly associated with development of multiple STs lesions and epidermal IGF-1 tissue immunoreactivity in studied patients.