الفهرس | Only 14 pages are availabe for public view |
Abstract Introduction Neonatal unconjugated hyperbilirubinemia is one of the most common problems in term newborns, defined as a total serum bilirubin level above 5 mg per dL. Up to 60 percent of term newborns have clinical jaundice in the first week of life but few have significant underlying disease .Prolonged hyperbilirubinemia can result in chronic bilirubin encephalopathy Aim of the work To evaluate to what extent the different levels of serum indirect bilirubin and iron status may affect the oxidative status in full-term neonates with unconjugated hyperbilirubinemia.The results of this study showed the following:Total serum bilirubin (TSB) showed significantly higher levels in subgroups (A&B) than control group. There were no significance differences between the studied groups in CBC parameters, serum iron, serum ferritin, TIBC and serum hepcidin levels.There was significantly higher level in Malondialdehyde (MDA) in both subgroups A&B relative to control group.There was no significant difference level in Total Anti-oxidant Capacity (TAC) in the studied groups.There were significant differences between subgroups A & B in serum TSB and serum ferritin levels. Conclusion:from the previous finding of this study it can be concluded that:1)Full-term neonates with jaundice due to unconjugated hyperbilirubinemia were exposed to more oxidative stress than healthy neonates without jaundice in spite of evidences of antioxidant of serum bilirubin.2)The serum level of hepcidin showed no significant differences between the studied groups and there were unexpected negative correlation between MDA and hepicidin level which indicate defective control of serum iron level among such neonates. |