الفهرس 
General introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
This study aims to investigate the antitumor activity of polyphenon-E (PE) in Ehrlich solid tumor in mice and enhancing their bioavailability by encapsulation in chitosan TPP nanoparticles (CSNPs). The current study was conducted on forty female albino mice injected with Ehrlich Ascites Carcinoma cells (EAC)) under skin in the back above the spinal cord. On day 5 the animals were randomized and divided into 4 groupsThe green tea polyphenols in a nano form treated group showed significant decrease in tumor weight and rate of increase in tumor volume .There was a significant decrease in the expression of PCNA, VEGF and CD31 in the polyphenols nano form treated group. The group polyphenols nano form showed the maximal arrest in cell cycle specifically at the G0/G1 phase. Annexin V showed the greater decrease in the viable cells and increase in the apoptotic cells in polyphenols nano form group. A significant increase in the apoptotic markers and decrease in the antiapoptotic markers in treated group with a maximal effect represented in the polyphenols nano form group. Treated groups showed increase in the antioxidant levels and decrease in the lipid peroxidation levels In conclusion, encapsulation of PE in chitosan nanoparticles provide good platform for cancer chemotherapy and possess strong rational for further trials with different cancers and raise exiting application of different polyphenols for nano-chemotherapy/ prevention.