الفهرس | Only 14 pages are availabe for public view |
Abstract The main objective of the current systematic review/metaanalysis was to compare different results of vitamin D supplementation in overweight/obese versus normal weight children and adolescents. The secondary objective was to compare the effectiveness of different supplementary doses of vitamin D in obese Children. Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 till November 2017) using a variety of Medical Subjects Headings and free text words: (vitamin D AND supplementation AND clinical trials AND children AND obesity). Outcomes intended after vitamin D supplementation were improvement of vitamin D status, BMI alteration as well as appetite changes. Ten researches were retrieved but only six were relevant. Further classification was done into meta-analysis I where supplemented obese children and adolescents were compared to non-obese controls and meta-analysis II where supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled results from the six studies revealed significantly lower vitamin D levels in obese compared to non-obese peers.Additionally, pooled risk from the two studies in meta-analysis I that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not receiving benefit from the vitamin D supplementation disregards the dose or the duration of supplementation. |