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Abstract Addiction is a chronic relapsing disorder characterized by neurological change lead to compulsive take drug with loose of control over drug intake. It begins in childhood and adolescence and is influenced by a tangle of factors involving genes, environment, and an individual’s age at first substance use. Whatever the addiction cigarettes, cannabis, illicit or prescription drugs are considered illegal when diverted from proper use as benzodiazepine, tramadol, flurest, dextromethorphane, parkinol. The current study was under taken to determine the common addicting drugs from urine and hair samples of 240 students volunteers: 120 students from three secondary schools (high secondary school, mechanical and decorative school, agriculture school) and 120 students from three colleges (faculty of tourism & hotels, faculty of science and faculty of social service) in Fayoum city. The first step was the screening test, which is applied to all samples. Screening tests are immunoassay(dipstick ) and TLC (Thin Layer chromotographer). The second step is (High-performance liquid chromatography) HPLC , known as the confirmation test, was only applied to positive samples during the screening test. The present study revealed that 40% cannabis, 23% benzodiazepine and 37% tramadol are more prevealent among school students than 25% flurest, 9% parkinol and 8% dextromethorphane which are more among students of colleges .The present study shows that the students in school are more poly drugs user 62.4% while the students of colleges are more single drug user 60.4%. In 2011, recent statistics in USA revealed that drug use among students of high schools & colleges increased to 81 % in the last five years. That figure mirrors the growth in prescription drug abuse with pain killers like oxycontin , valium and tramadol which became the second most abused drugs, behind marijuana. People often become addicted to pain killers when they take them for legitimate reasons, such as surgery. The drugs make patients feel euphoric, leading them to want that feeling more. |