الفهرس 
Introduction
Chapter 1: Acute coronary syndromesOnly 14 pages are availabe for public view
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Abstract
Our study included 80 consecutive Pts, [51 males (63.8%), 29females (36.2%), with a mean age ± SD of 57.42 ± 10.3 years, diagnosed as NSTE-ACS at CCU of EL-Minia University Hospital in the period from July 2016 to April 2017.
The aim of this study was to determine, would the level of prolactin detect early diagnosis of NSTE – ACS?? , Would the level of prolactin predict prognosis of NSTE - ACS?, Would the level of prolactin correlate with grace risk score??
All patients were subjected to the following:
1- Full history taking.
2- Clinical examination.
3- Serial ECG recording.
4- Echocardiographic assessment.
5- All Pts were received the traditional treatment of ACS unless presence of contraindication or intolerance.
6- Laboratory investigations.
Routine investigation
Random blood glucose, renal function test and lipid profile.
Special investigation
• Serum Troponin I which the samples were collected at time of admission and after 12 hs from onset of chest pain)
• Serum Prolactin levels which the Samples were collected at the time of admission and after 12 hs from onset of chest pain.
Results
The NSTEMI-ACS Pts had serum prolactin level above normal range, and prolactin level was higher in NSTEMI patients than un-stable angina. The cutoff point of the 1st prolactin level at which we can diagnosis of NSTEMI) was more than 15ng/dl in male Pts with 100% sensitivity and 83%, specificity, and the cutoff point in female Pts was more than 18ng/dl with 100% sensitivity and 80% Specificity.
NSTEMI Pts with positive troponin and high level of prolactin had more incidence of MACE than un-stable angina Pts, and there was a positive correlation between the prolactin level and occurrence of MACE. The cutoff point of 1st prolactin level for early prediction of occurrence MACE in NSTEMI male patients was more than 18 ng/ml with 100% sensitivity, specificity, accuracy while in female patients was more than 21ng/ml with 87.5% sensitivity , 100 % specificity and 91.7% accuracy. The cutoff point in un-stable angina male Pts was more than 11ng/ml with 100% sensitivity, 88.89 % specificity and 88.89% accuracy, while in female patents was more than 18ng/ml with 75% sensitivity, 100% specificity and 94.3% accuracy.
There was a high GRACE score in NSTEMI patients than un-stable angina, and there was no correlation between level of prolactin and GRACE score.