الفهرس 
DECLARATIONOnly 14 pages are availabe for public view
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Abstract
• Objectives
The objectives of the current thesis can be summarized as follows:
• Construct and refine homology models for the LTB4 receptors.
• Understand the probable receptor structure.
• Understand the innate mechanism of the developed ligands and design more potent small molecules based on modeling studies.
• Design antagonist molecules which effectively fit to each LTB4 receptor.
• Analyze interaction patterns of existing ligands using quantum mechanics, molecular mechanics and quantum mechanics/molecular mechanics computational methods, as well as molecular dynamics techniques
• Synthesize potent lead compounds towards LTB4 receptors.
• The outcomes can be summarized as follows:
• Construction of homology models for the BLT1 and BLT2 receptors.
• Better understanding of the ligand-BLT1 and –BLT2 interactions.
• Discovery of potent lead compounds towards BLT1 and BLT2 receptors.