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Abstract SUMMARY AND CONCLUSION Rotator cuff diseases are one of the most common causes of chronic shoulder pain and disability. It can occur to anyone during everyday activities or with chronic overuse. The diagnosis of rotator cuff tendinopathy, with partial thickness tendon tears and tendonosis, constitutes more than 50 % of cases presenting with shoulder pains. Conservative treatments, such as avoiding activities that cause pain, non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy and exercises are regarded as the main stay treatment. Corticosteroid injection is a commonly administered treatment for tendon disorders. The use of platelet-rich plasma (PRP) as a biological solution to improve rotator cuff tendon healing has gained popularity over the last several years. PRP is a whole blood fraction containing high platelet concentrations that, once activated, provides a release of various growth factors (GFs) that participate in tissue repair processes. The efficacy of this treatment modality remains unproven, and there is little and often inconclusive evidence to guide clinicians as to the value of this therapy. |