الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Introduction : Multiple sclerosis (MS), is a chronic autoimmune neuro-inflammatory disorder of the central nervous system (CNS), is characterized by multiple foci of demyelination of the CNS. Clinical courses of MS are different. Mostly, the patients at the beginning of the disease have episodes of reversible neurological deficits, and then followed by progressive neurological deterioration with time (Goldenberg, 2012). The exact cause of MS still unknown, it may be due to a combination of genetic and non-genetic factors, these factors together can lead to recurrent immune attacks in the CNS (Wang et al., 2014). Multiple sclerosis causes bothersome or disabling physical symptoms involving mobility problems, vision problems, problems with coordination, cognitive dysfunction, fatigue, and pain. Quality of life may be further reduced by mood disorders and limitations in employment and social functioning (Feinstein, 2011). MS patients are classified by neurologists into four major categories according to the course of the disease: 1. Relapsing remitting MS, 2. Secondary progressive MS, 3. Primary progressive MS and 4. Progressive-relapsing MS (Hauser and Goodwin, 2008). MS was thought to be a T helper 1 (Th1) cell driven, but the scientists had discovered other T helper cells called T helper 17 (Th17) cells, which are participate in the development of MS (Wang et al., 2014). The Th17 cells are the main source of interleukin 17 (IL-17) cytokine family which include six members from (IL17A-F), these cytokines play an important role in the activation of many immune cells as; T cells, dendritic cells, peripheral blood mononuclear cells (PBMCs) and fibroblasts (Digre et al., 2017). IL-17 concentration is found to be elevated in patients with MS and it is also involved in the progression of active experimental autoimmune encephalomyelitis (EAE). These results can confirm the participation of IL-17 in the mechanism of MS (Wang et al., 2014). Introduction and Aim of the work 2 Polymorphism in the genes of the cytokine, can lead to either increase or decrease the production of these cytokines (Laine et al., 2012). So the polymorphism affecting the expression or activity of IL-17 may affect the susceptibility and severity of autoimmune diseases as MS. IL-17F gene is found on the longer arm of chromosome 6, on 6q12 position (Paradowska-Gorycka et al., 2010), the polymorphisms of IL-17F have found to be associated with increase the susceptibility to rheumatoid arthritis (Nordang et al., 2009), ulcerative colitis (Arisawa et al., 2008) and with multiple sclerosis in Chinese population (Wang et al., 2014). So early discover the association between the gene polymorphism and MS disease in Egyptian will help in early diagnosis, treatment and prevention of marked neurological deteriorations.