الفهرس 
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Abstract
The aim of the study was to evaluate the efficacy of prophylactic nifedipine versus placebo in reducing spontaneous preterm delivery in asymptomatic women at high risk for preterm delivery.
Patients:
This study was designed as a Prospective randomized double-blinded one, and carried out on 110 pregnant women at high risk of preterm labor.
Patients were classified randomly into the following equal groups using online software (https://www.randomizer.org); numbers were concealed in closed envelopes.
group A: include 55 pregnant patient who at high risk for preterm labor they received placebo, the placebo contained folic acid (folic acid 5mg,Nile,Egypt) for 28 days.
group B: include 55 pregnant patient who at high risk for preterm labor they received nifedipine 20 mg tablets (Epilat Retard®, EIPICO, Egypt) once daily for 28 days.
Data collection:
All patients underwent complete clinical examination and detailed medical history was obtained. Each patient had a Case Record Form (CRF) in which the following data were recorded:
1. Patient initials.
2. Patient number (according to the randomization schedule).
3. Age, height, weight
4. Known allergies.
5. Past medical and surgical history.
6. Medications taken within the last 4 weeks and discontinued.
7. Concomitant illnesses.
8. Concomitant medications which would not be discontinued.
9. Clinical examination: including chest and abdominal examination.
Main outcome measures:
Primary end point: spontaneous preterm delivery <37 weeks in nifedipine versus placebo (mean prolongation of pregnancy and perinatal outcome).
Secondary outcomes: maternal side effects, neonatal complications, admissions to the Neonatal Intensive Care Unit and need for mechanical ventilator
Statistical analysis
The data were collected, tabulated and statistically analyzed.
Results
The results of our study showed the superiority of nifedipine in the mean prolongation of pregnancy compared to that of placebo in high risk women for preterm labor; it has better effect on neonatal outcomes, fewer maternal side effects. On the basis of this study nifedipine appears to be safe and well tolerated, non-invasive and effective method of preventing uterine contractions in high risk women for preterm labor.