الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 152 |  |  |
| | | from | 152 | | |
Abstract
Bronchopulmonary dysplasia (BPD) defined as oxygen dependency at 36 weeks postmenstrual age (PMA), is the most important complication of prematurity with a reported incidence of 23% in infants born at 28 weeks and increasing to 73% in infants born at 23 weeks . Interleukins are chemicals made by one cell type that act on other inflammatory cells. They may induce growth, differentiation and proliferation of other leukocytes. They may also act as chemo-attractants for recruitment of other cell types (immune and non-immune cells) to a site of injury,and may exert pro-or anti inflammatory effect , Corticosteroids have a strong anti-inflammatory effect, making them an ideal candidate to attenuate the inflammatory response associated with BPD The aim of the work is to assess.if IL6 and 8 have a role in prediction & development of BPD and if inhaled budesonide have effect on these interleukins and ultimately on the prevention of BPD. Results from our study showed that shows no statistically significant differences between study and control groups regarding the demographic dat Results of our study showed significantly lower rates of death (2 versus 7) and BPD (1 versus 4) in the study group as compared to the control group.
Regarding interleukin level, IL-6 level of (450 pg/ml) had sensitivity of 100 % and specificity of 69.2 % before treatment , and after 7 days (either received budesonide or not) a level of (241.5 pg/ml) had sensitivity of 100 % and specificity of 69.2 % and IL-8 level of (1779 pg/ml) had sensitivity of 100 % and specificity of 61.5 % before treatment , and after 7 days (either received budesonide or not) a level of (935.5 pg/ml) had sensitivity of 100 % and specificity of 76.9 % .Results of our study showed shows significantly higher tracheal aspirate IL-6 and IL-8 levels before and after treatment in BPD patients when compared with patients free from BPD. We concluded from this study that inhaled budesonide resulted in significant reduction of IL-6 and IL-8 in the tracheal aspirate.This was associated with significant reduction in the prevention of BPD without causing significant increase in morbidity.We recommended that inhaled budesonide may be a useful tool for prevention of BPD in preterm babies and a larger study is recommended to confirm results of the present study.