الفهرس 
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Abstract
Summary Psoriasis is a common disease, with a prevalence rate of about 1 to 3 percent of population. Researches have shown that psoriasis is systemic inflammatory disea Psoriasis is a common disease, with a prevalence rate of about 1 to 3 percent of population. Researches have shown that psoriasis is systemic inflammatory disease, which results from an imbalance in lymphocytes (Th1 and Th17) and dendritic cells, also it may result from genetic factor. Psoriasis does not only affect the skin, but also extends to other organs, leading to increased susceptibility to certain diseases such as atherosclerosis, angina, diabetes and hypertension. Thus, acting as many other auto immune diseases such as rheumatoid arthritis, multiple sclerosis and Crohn’s disease. Vitamin D is the vitamin that controls calcium absorption and bones calcification. It has been well known for decades that its deficiency causes rickets in children and osteoporosis in adults. Researches have shown that this vitamin plays a crucial role in regulating immune system performance through lymphocytes (Th1 and Th17) and dendritic cells. In addition, it has an important role in regulating keratinocytes differentiation in the skin. This may be explained by some studies of vitamin D deficiency associated with many diseases such as cardiovascular disease, diabetes and also immunological diseases such as rheumatoid arthritis, lupus erythematosus, Crohn’s disease and other immune inflammatory diseases, which includes psoriasis.Research has shown low serum levels of vitamin D in patients with psoriasis.For many years, it has been known that the topical vitamin D compounds have been used effectively in treating psoriasis vulgaris but have not been used orally or parenterally in psoriasis treatment except in very few studies. Recent information about the impact of vitamin D deficiency on psoriasis patients may provide a new research tool for using oral and parenteral vitamin D for the treatment of psoriatic patients. Regarding available informations, studies on the level of vitamin D in psoriatic patients in our region are very few, which prompted us to do this research to study the level of vitamin D in patients with psoriasis vulgaris and its relationship as a disease compared to healthy people.The study included those who were selected from the outpatient clinic of the Department of Dermatology, Andrology & STDs in Mansoura University Hospital. Patients were conducted on two groups: patient group and control group. Patients group included 40 patients with chronic plaque psoriasis and the second group is a control group of volunteers who do not suffer from psoriasis and who match with psoriasis patients in age, sex, body mass index and daily exposure to sunlight. We excluded patients under medical treatment or patients suffering from diseases that may affect the level of vitamin D in the blood.