الفهرس | Only 14 pages are availabe for public view |
Abstract Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbance of carbohydrate, lipid and protein metabolisms resulting from defects in insulin secretion. DM enhanced oxidative stress and lipid peroxidation due to generation of reactive oxygen species (ROS) and free radicals, which lead to diabetes complications. Morbidity & mortality in diabetic animals caused by its complication. Streptozotocin (STZ) is used to induce diabetes in experimental animals through its toxic effects in pancreatic β cells and as a potential inducer of oxidative stress, which produced a perfect model of diabetes mellitus (DM). Nowadays, all studies aimed to find natural remedy to DM & its complication with minimum side effects. C. papaya leaves aqueous extract exhibited anti-hyperglycemic & anti-hyperlipidimic properties with hepato-protective effect& nephroprotective effect, that effect is due to its flavonoids content and vitamin E. Ninetyclinically healthy albino rats with average 100gm body weight, were divided randomly into 6 group; GP. (I): 15 normal control rats as rats kept without treatment. GP. (II): 15diabetic rats were injected by a single IP STZ in a dose 65 mg/kg BW.GP. (III): 15 rats just received C. papaya leaves aqueous extractall experimental period by a dose 0.11g/ml.GP. (IV): 15 rats received firstly C. papaya leaves aqueous extractby a dose 0.11g/ml then induced diabetes by STZ injection then continue with our extract by. |