الفهرس 
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Abstract
A total of thirty apparently healthy New Zealand white
mature rabbits each weighing between 2 and 2.5 kg were
included in this study (Twenty females for the experimental
work and ten male for preparation of stem cells). Two identical
one cm full-thicknesses, circular wounds were created down to
the cartilage on the ventral surface of each ear pinna under
complete aseptic condition. The right ear was used as a control
whiles the left one for the treatment. Two groups (each group
contains 10 rabbits) were used as following:
1. group A: BMD-MSC (Bone Marrow derived –
Mesenchymal stem cells) was injected into the wound bed.
2. group B: Corticosteroids (Triamcinolone acetonide) was
injected into the wound bed.
Stem cells and corticosteroids (TAC) used to inhibit
the growth level of hypertrophic scar .The group injected with
MSCs showed down-regulation of MMP-9, IL-6 and IL-1β
genes lower than those injected with TAC. Also the present
study observed up-regulation of TGF-β1, TGF-β2 and TIMP-1
genes of MSCs-treated group higher than TAC-treated one.
Vascular endothelial growth factor (VEGF) plays an
important role in wound healing through its pro-angiogenic
ability and reduction of scar formation. Here in, we examined.