الفهرس 
Differential-pulse voltammetryOnly 14 pages are availabe for public view
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Abstract
Currently, electrochemical sensors have become very promising analytical tool for quantification of the analyte concentration in different samples. This is because of their selectivity and sensitivity in sample quantification. Therefore, they can be used extensively in clinical diagnostics, occupational safety, medical engineering, quality control, and environmental analysis. Nanomaterials are usually used to take advantage of a larger surface area for biomolecules to be immobilized. This generally increases the number of binding sites available for the detection of a specific chemical analyte. Various types of nanomaterials are used as electrochemical sensors. Carbon nanotubes (CNTs) are one of the most exciting materials because of their unique electronic, chemical, and mechanical properties. Also, Graphene (GR) plays attractive role in electrochemical sensors development because of its electrical conductivity, high surface area, crystalline surface and its mechanical properties. Moreover, mesoporous silica (SBA-15) has spread widely nowadays in many sensing applications. This wide-spread of silica may result from its pores structures, and consequently its high surface area which enhance the sorption behavior in its surface. Furthermore, iron oxide-graphene (Fe3O4-GR) nano-composite has elegant application in sensing application. This is due to the combination of graphene properties and the electrical, magnetic, and catalytic properties of iron oxide nano particles. So, the main aim of this work is development of new kinds of electrochemical sensors based on carbon nano-tubes, mesoporous silica, Graphene (GR ) and Fe3O4-GR nanomaterials for enhancement the performance of CPE in analysis of some drugs. This was carried out initially by functionalization of pristine MWCNT, prepration of mesoporous silica, prepration of Fe3O4 nanoparticles, and prepration of Fe3O4-GR nanocomposite, and their characterization using several techniques. The second step is preparation and characterization of some chemically modified CPE electrodes using such nanomaterials. Finally, these modified electrodes were utilized for trace determination of some biologically active compounds (such as Domperidone, Dapoxetien hydrochloride and Olanzapine) in pure form, pharmaceutical formulations and in biological fluids. A comparative study of the results of the voltammetric methods with those obtained by the chromatographic, and/or spectrophotometric methods for determination of same drugs was also done.