الفهرس 
Introduction
Chapter 1 : Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Nesfatin-1 found in many regions of the hypothalamus and spinal cord and autonomic nuclei. It is also located in the pancreas which indicates the possibility of post Nesfatin-1 in regulating insulin secretion from beta cells in the pancreas.
The reduction in fasting plasma level of Nesfatin-1 and increase levels after re feeding this suggests that Nestafin-1 plays an important role in regulating satiety, and perhaps energy balance.
Obesity mainly produces excessive ingestion of food or reduces energy expenses, a problem associated with insulin resistance and diabetes type 2.
The Nestafin-1 plays an important role in regulating body weight and insulin secretion.
The aim of the present study is assessment of plasma level of nesfatin-1 and its association with various metabolic parameters in newly diagnosed type 2 diabetic patients.
We hypothesized that Nestafin-1 levels in plasma may be affected by insulin resistance in the cases that have been newly diagnosed with diabetes type 2 and cases of impaired glucose tolerance.
In this study we aimed to evaluate the levels of Nestafin-1 and relate it to different clinical and laboratory parameters in type 2 diabetes mellitus in some Egyptian population .
Our study included 90 subjects classified into three groups “ group Ґ” included 30 newly diagnosed type 2 diabetic patients , group II ” included 30 pre diabetic patients, group III ” included 30 healthy subjects.
Both patients and controls were subjected to full history, thorough clinical examination, anthropometric measurements including weight, height, BMI, laboratory examination of glycated haemoglobin HbA1c, Fasting and 2h post prandial blood glucose, Liver function tests (bilirubin, AST, ALT, total total bilirubin, direct bilirubin, serum albumin). Complete Blood Count (CBC). serum creatinine, serum urea, total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, Nesfain-1.
In this study on comparing all groups with Nesfatin-1 there was a statistical significant difference regarding (SBP, DBP, Waist Circumference, BMI, Waist/Hip ratio, FBG, 2hpp BG, F. insulin, HbA1c,HOMA B, HOMA ir, T. cholesterol, Triglycerides, HDL, LDL.
We found significantly lower nesfatin-1 levels in diabetic patients (Type 2 DM) but less lower in prediabetic patients (IGT) in comparison to control .
from this we recommend that It is important to clarify the relationship between Nesfatin-1 and insulin resistance in relation to diabetes. To clarify its physiological role and that further studies are required on this subject.