الفهرس 
AcknowledgementsOnly 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
MS is characterized by impairment in cognitive domains. Sensory memory is one of the cognitive domains affected in MS. MMN allows the brain to detect (via a comparator mechanism) deviant events occurring within a stream of repetitive stimuli. The amplitude and latency of the MMN has been used to elucidate the nature of the sensory memory upon which it is based. This work was designed to evaluate and measure the MMN test results as regard its amplitude and latency in MS patients and to compare the results with normal age and gender matched control group. It was a case control study encompassing 40 subjects divided into study group and control group. MS patients fulfilled the revised McDonald diagnostic criteria of MS. In this study, MMN was elicited using odd ball paradigm in which we used 1000 Hz tone burst as standard stimulus and 1500 Hz tone burst as a deviant stimulus. Absence of MMN wave was observed in 20% of MS patients. T-test was used to compare MMN latencies and also MMN amplitude between both groups. MMN latencies and amplitudes were statistically insignificant between the study group and the control group No correlation was found between the duration of the disease and MMN measured parameters. No correlation was found between the EDSS and MMN measured parameters. Conclusions MMN test results showed no significant difference between the study and control groups. However, the absence of MMN in some MS patients suggests affection of the central auditory processing abilities measured by MMN in those patients which need further research.